16th EDRA Webinar - June 24th, 2025

Dr. Françoise Dantzer, Keynote speaker

Poly(ADP-ribosyl)ation and Genome Integrity, Strasbourg drug discovery and development Institute (IMS), UMR7242, Centre Nationale de la Recherche Scientifique/Université de Strasbourg, Institut de Recherche de l’Ecole de Biotechnologie de Strasbourg

Molecular and functional aspects of PARP3 in physiological and pathological processes

Poly(ADP-ribose) polymerase 3 (PARP3) has been primarily characterized for its role in the DNA damage response and mitotic progression. Recent studies have expanded its functional scope to include critical roles in (i) physiological processes such as neurogenesis by promoting astrocytic differentiation and myogenesis by fostering myogenic differentiation and muscle function (ii) and in pathophysiological events precisely in tumor aggressiveness under conditions of reduced PARP1 expression. Notably, share features emerge in both contexts, particularly involving physical traits of the cell such as migration, cytoskeleton rearrangements, ECM remodeling, adhesion among others. This convergence is especially striking considering the predominantly nuclear localization of the protein and its mechanistic properties in DNA repair and transcriptional regulation. Our current research is aimed at addressing these questions and investigating how PARP3 influences cell plasticity and mechanical adaptability in aggressive tumor contexts.

Apply for the two selected short talks from young investigators (15 min + 5 min questions).